tailieunhanh - Báo cáo y học: "Statistical considerations in a systematic review of proxy measures of clinical behaviour"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Statistical considerations in a systematic review of proxy measures of clinical behaviour | Dickinson et al. Implementation Science 2010 5 20 http content 5 1 20 Implementation Science IMPLEMENTATION SCIENCE RESEARCH ARTICLE Open Access Statistical considerations in a systematic review of proxy measures of clinical behaviour Heather O Dickinson1 Susan Hrisos1 Martin P Eccles1 Jill Francis2 Marie Johnston3 Abstract Background Studies included in a related systematic review used a variety of statistical methods to summarise clinical behaviour and to compare proxy or indirect and direct observed methods of measuring it. The objective of the present review was to assess the validity of these statistical methods and make appropriate recommendations. Methods Electronic bibliographic databases were searched to identify studies meeting specified inclusion criteria. Potentially relevant studies were screened for inclusion independently by two reviewers. This was followed by systematic abstraction and categorization of statistical methods as well as critical assessment of these methods. Results Fifteen reports of 11 studies met the inclusion criteria. Thirteen analysed individual clinical actions separately and presented a variety of summary statistics sensitivity was available in eight reports and specificity in six but four reports treated different actions interchangeably. Seven reports combined several actions into summary measures of behaviour five reports compared means on direct and proxy measures using analysis of variance or t-tests four reported the Pearson correlation none compared direct and proxy measures over the range of their values. Four reports comparing individual items used appropriate statistical methods but reports that compared summary scores did not. Conclusions We recommend sensitivity and positive predictive value as statistics to assess agreement of direct and proxy measures of individual clinical actions. Summary measures should be reliable repeatable capture a single underlying aspect of behaviour and map .