tailieunhanh - Báo cáo y học: " The pulmonary effects of intravenous adenosine in asthmatic subjects"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:The pulmonary effects of intravenous adenosine in asthmatic subjects. | Respiratory Research BioMed Central Research Open Access The pulmonary effects of intravenous adenosine in asthmatic subjects Nausherwan K Burki 1 Mahmud Alam2 and Lu-Yuan Lee2 Address 1Division of Pulmonary Critical Care Medicine Department of Medicine University of Connecticut Health Center Farmington CT USA and 2Department of Physiology University of Kentucky Medical Center Lexington KY USA Email Nausherwan K Burki - nburki@ Mahmud Alam - edumaqam1@ Lu-Yuan Lee - lylee@ Corresponding author Published 30 November 2006 Received 29 June 2006 Accepted 30 November 2006 Respiratory Research 2006 7 139 doi 1465-9921-7-139 This article is available from http content 7 1 1 39 2006 Burki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We have shown that intravenous adenosine in normal subjects does not cause bronchospasm but causes dyspnea most likely by an effect on vagal C fibers in the lungs Burki et al. J Appl Physiol 2005 98 180-5 . Since airways inflammation and bronchial hyperreactivity are features of asthma it is possible that intravenous adenosine may be associated with an increased intensity of dyspnea and may cause bronchospasm as noted anecdotally in previous reports. Methods We compared the effects of placebo and 10 mg intravenous adenosine in 6 normal and 6 asthmatic subjects. Results Placebo injection had no significant p effect on the forced expiratory spirogram heart rate minute ventilation Ve or respiratory sensation. Similarly adenosine injection caused no significant changes p in the forced expiratory spirogram however there was a rapid development of dyspnea as signified visually on a modified Borg scale and a .

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