tailieunhanh - Báo cáo y học: " Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis. | Respiratory Research BioMed Central Research Open Access Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis Richard Kraemer 1 2 David N Baldwin2 Roland A Ammann1 Urs Frey1 2 and Sabina Gallati1 3 Address Department of Paediatrics University of Berne Inselspital CH-3010 Berne Switzerland. 2Division of Pediatric Respiratory Medicine Department of Pediatrics University of Berne Inselspital CH-3010 Berne Switzerland. and 3Division of Human Genetics Department of Pediatrics University of Berne Inselspital CH-3010 Berne Switzerland. Email Richard Kraemer - David N Baldwin - dn_baldwin@ Roland A Ammann - Urs Frey - Sabina Gallati - Corresponding author Published 30 November 2006 Received 07 August 2006 Accepted 30 November 2006 Respiratory Research 2006 7 138 doi 1465-9921-7-138 This article is available from http content 7 1 1 38 2006 Kraemer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Functional deterioration in cystic fibrosis CF may be reflected by increasing bronchial obstruction and as recently shown by ventilation inhomogeneities. This study investigated which physiological factors airway obstruction ventilation inhomogeneities pulmonary hyperinflation development of trapped gas best express the decline in lung function and what role specific CFTR genotypes and different types of bronchial infection may have upon this process. Methods Serial annual lung function tests performed in 152 children 77 males 75 females with CF age range 6-18 y provided data pertaining to functional