tailieunhanh - Báo cáo y học: " Airway smooth muscle as a target of asthma therapy: history and new directions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Airway smooth muscle as a target of asthma therapy: history and new directions. | Respiratory Research BioMed Central Open Access Review Airway smooth muscle as a target of asthma therapy history and new directions Luke J Janssen and Kieran Killian Address Firestone Institute for Respiratory Health St. Joseph s Hospital and the Department of Medicine McMaster University Hamilton Ontario L8N 3Z5 Canada Email Luke J Janssen - janssenl@ Kieran Killian - killiank@ Corresponding author Published 29 September 2006 Received 28 July 2006 Accepted 29 September 2006 Respiratory Research 2006 7 123 doi 1465-9921-7-123 This article is available from http content 7 1 123 2006 Janssen and Killian licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Ultimately asthma is a disease characterized by constriction of airway smooth muscle ASM . The earliest approach to the treatment of asthma comprised the use of xanthines and anti-cholinergics with the later introduction of anti-histamines and anti-leukotrienes. Agents directed at ion channels on the smooth muscle membrane Ca2 channel blockers K channel openers have been tried and found to be ineffective. Functional antagonists which modulate intracellular signalling pathways within the smooth muscle P-agonists and phosphodiesterase inhibitors have been used for decades with success but are not universally effective and patients continue to suffer with exacerbations of asthma using these drugs. During the past several decades research energies have been directed into developing therapies to treat airway inflammation but there have been no substantial advances in asthma therapies targeting the ASM. In this manuscript .

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