tailieunhanh - Báo cáo y học: "Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults. | Respiratory Research BioMed Central Research Open Access Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults Dahui You David Becnel Kai Wang Michael Ripple Melissa Daly and Stephania A Cormier Address Louisiana State University Department of Biological Sciences Baton Rouge USA Email Dahui You - dyou1@ David Becnel - dbecne1@ Kai Wang - kwang@ Michael Ripple - mrippl1@ Melissa Daly - mdaly2@ Stephania A Cormier - scormier@ Corresponding author Published 07 August 2006 Received 27 March 2006 Respiratory Research 2006 7 107 doi 1465-9921-7-107 Accepted 07 August 2006 This article is available from http content 7 1 107 2006 You et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Respiratory syncytial virus RSV is the most common cause of acute bronchiolitis in infants and the elderly. Furthermore epidemiological data suggest that RSV infection during infancy is a potent trigger of subsequent wheeze and asthma development. However the mechanism by which RSV contributes to asthma is complex and remains largely unknown. A recent study indicates that the age of initial RSV infection is a key factor in determining airway response to RSV rechallenge. We hypothesized that severe RSV infection during neonatal development significantly alters lung structure and the pulmonary immune micro-environment and thus neonatal RSV infection is crucial in the development of or predisposition to allergic inflammatory diseases such as asthma. Methods To investigate this hypothesis the present study was conducted in a neonatal mouse model of RSV-induced pulmonary inflammation and airway .