tailieunhanh - Báo cáo y học: " Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an α-smooth muscle actin-Cre transgenic mouse"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an α-smooth muscle actin-Cre transgenic mouse. | Respiratory Research BioMed Central Open Access Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an a-smooth muscle actin-Cre transgenic mouse Zhuang Wu11 Leilei Yang12 Lin Cai1 Min Zhang1 Xuan Cheng2 Xiao Yang 2 and Jun Xu 1 Address 1Guangzhou Institute of Respiratory Disease First Affiliated Hospital of Guangzhou Medical College Guangzhou 510120 P. R. China and 2Genetic Laboratory of Development and Diseases Institute of Biotechnology 20 Fengtai Eastern Street Beijing 100071 Email Zhuang Wu - wuzhuang@ Leilei Yang - qqneversaydie@ Lin Cai - lin_cai@ Min Zhang - zhangmincc@ Xuan Cheng - xuan_cheng@ Xiao Yang - yangx@ Jun Xu -xufeili@ Corresponding authors fEqual contributors Published 07 January 2007 Received 02 September 2006 Respiratory Research 2007 8 1 doi 1465-9921-8-1 Accepted 07 January 2007 This article is available from http 1465-9921 8 1 2007 Wu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Epithelial to mesenchymal transition EMT in alveolar epithelial cells AECs has been widely observed in patients suffering interstitial pulmonary fibrosis. In vitro studies have also demonstrated that AECs could convert into myofibroblasts following exposure to TGF-P1. In this study we examined whether EMT occurs in bleomycin BLM induced pulmonary fibrosis and the involvement of bronchial epithelial cells BECs in the EMT. Using an a-smooth muscle actin-Cre transgenic mouse a-SMA-Cre R26R strain we labelled myofibroblasts in vivo. We also performed a phenotypic analysis of human BEC lines during TGF-P1 stimulation in vitro. .

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