tailieunhanh - Báo cáo y học: "Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells. | Respiratory Research BioMed Central Open Access Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells Bernd Schmeck1 Kerstin Moog1 Janine Zahlten1 2 Vincent van Laak1 Philippe Dje N Guessan1 Bastian Opitz1 Simone Rosseau1 Norbert Suttorp1 and Stefan Hippenstiel 1 Address Department of Internal Medicine Infectious Diseases and Respiratory Medicine Charité - Universitatsmedizin Berlin 13353 Berlin Germany and 2Department of Peridontology and Synoptic Dentistry Charité - Universitatsmedizin Berlin 13353 Berlin Germany Email Bernd Schmeck - Kerstin Moog - Janine Zahlten - Vincent van Laak - Philippe Dje N Guessan - Bastian Opitz - Simone Rosseau - Norbert Suttorp - Stefan Hippenstiel - Corresponding author Published 12 July 2006 Received 30 December 2005 Respiratory Research 2006 7 98 doi 1465-9921 -7-98 Accepted 12 July 2006 This article is available from http content 7 1 98 2006 Schmeck et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Although pneumococcal pneumonia is one of the most common causes of death due to infectious diseases little is known about pneumococci-lung cell interaction. Herein we tested the hypothesis that pneumococci activated pulmonary epithelial cell cytokine release by c-Jun-NH2-terminal kinase JNK Methods Human bronchial epithelial cells BEAS-2B or epithelial HEK293 cells were infected with s. pneumoniae R6x and cytokine induction was .