tailieunhanh - Báo cáo khoa học: DYNLL/LC8: a light chain subunit of the dynein motor complex and beyond

The LC8 family members of dynein light chains (DYNLL1 and DYNLL2 in vertebrates) are highly conserved ubiquitous eukaryotic homodimer pro-teins that interact, besides dynein and myosin 5a motor proteins, with a large (and still incomplete) number of proteins involved in diverse biologi-cal functions. | IFEBS Journal MINIREVIEW DYNLL LC8 a light chain subunit of the dynein motor complex and beyond Peter Rapali Aron Szenes László Radnai Anita Bakos Gabor Pal and László Nyitray Department of Biochemistry Eotvos Lorand University Budapest Hungary Keywords dynein hub protein intracellular transport linear motif protein-protein interactions Correspondence L. Nyitray Department of Biochemistry Eotvos Lorand University Pazmany . 1 c H-1117 Budapest Hungary Fax 36 381 2172 Tel 36 1381 2171 E-mail nyitray@ Received 8 February 2011 revised 11 May 2011 accepted 15 June 2011 The LC8 family members of dynein light chains DYNLL1 and DYNLL2 in vertebrates are highly conserved ubiquitous eukaryotic homodimer proteins that interact besides dynein and myosin 5a motor proteins with a large and still incomplete number of proteins involved in diverse biological functions. Despite an earlier suggestion that LC8 light chains function as cargo adapters of the above molecular motors they are now recognized as regulatory hub proteins that interact with short linear motifs located in intrinsically disordered protein segments. The most prominent LC8 function is to promote dimerization of their binding partners that are often scaffold proteins of various complexes including the intermediate chains of the dynein motor complex. Structural and functional aspects of this intriguing hub protein will be highlighted in this minireview. doi Introduction Dynein light chains molecular mass 10-20 kDa are accessory subunits of the large dynein motor complexes. The LC8 family of light chains DYNLL1 and DYNLL2 in vertebrates abbreviated here as LC8 together with the Tctex DYNLT1 and DYNLT3 and LC7 Roadblock DYNLRB1 DYNLRB2 light chains bind as homodimers to the dimeric cytoplasmic dynein intermediate chains DYNC1I1 DYNC1I2 abbreviated here as DIC which are scaffold subunits for cargo binding to the motor complex for recent reviews see 1-3 a schematic view of the .

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