tailieunhanh - Báo cáo y học: "Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices. | Respiratory Research BioMed Central Research Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices Renate Paddenberg Peter Konig Petra Faulhammer Anna Goldenberg Uwe Pfeil and Wolfgang Kummer Open Access Address University of Giessen Lung Center Institute for Anatomy and Cell Biology Justus-Liebig-University Giessen Germany Email Renate Paddenberg - Peter Konig - Petra Faulhammer - Anna Goldenberg - Uwe Pfeil - Wolfgang Kummer - Corresponding author Published 29 June 2006 Received 21 April 2006 Respiratory Research 2006 7 93 doi 1465-9921 -7-93 Accepted 29 June 2006 This article is available from http content 7 1 93 2006 Paddenberg et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Acute alveolar hypoxia causes pulmonary vasoconstriction HPV which serves to match lung perfusion to ventilation. The underlying mechanisms are not fully resolved yet. The major vascular segment contributing to HPV the intra-acinar artery is mostly located in that part of the lung that cannot be selectively reached by the presently available techniques . hemodynamic studies of isolated perfused lungs recordings from dissected proximal arterial segments or analysis of subpleural vessels. The aim of the present study was to establish a model which allows the investigation of HPV and its underlying mechanisms in small intra-acinar arteries. Methods Intra-acinar arteries of the .