tailieunhanh - Báo cáo y học: " Decorin and TGF-β1 polymorphisms and development of COPD in a general population"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Decorin and TGF-β1 polymorphisms and development of COPD in a general population. | Respiratory Research BioMed Central Research Open Access Decorin and TGF-fil polymorphisms and development of COPD in a general population Cleo C van Diemen1 Dirkje S Postma2 Judith M Vonk1 Marcel Bruinenberg3 Ilja M Nolte3 and H Marike Boezen 1 Address Department of Epidemiology University Medical Center Groningen University of Groningen Groningen The Netherlands 2Department of Pulmonology University Medical Center Groningen University of Groningen Groningen The Netherlands and 3Department of Medical Biology University Medical Center Groningen University of Groningen Groningen The Netherlands Email Cleo C van Diemen - Dirkje S Postma - Judith M Vonk - Marcel Bruinenberg - Ilja M Nolte - H Marike Boezen - Corresponding author Published 16 June 2006 Received 22 December 2005 Respiratory Research 2006 7 89 doi l465-992l-7-89 Accepted 16 June 2006 This article is available from http content 7 l 89 2006 van Diemen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Decorin an extracellular matrix ECM proteoglycan and TGF-fii are both involved in lung ECM turnover. Decorin and TGF-fii expression are decreased respectively increased in COPD lung tissue. Interestingly they act as each other s feedback regulator. We investigated whether single nucleotide polymorphisms SNPs in decorin and TGF-fy underlie accelerated decline in FEV1 and development of COPD in the general population. Methods We genotyped 1390 subjects from the Vlagtwedde Vlaardingen cohort. Lung function was measured every 3 years for a period of 25 years. We tested whether