tailieunhanh - Báo cáo y học: " Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis. | Respiratory Research BioMed Central Open Access Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis Hartmut Grasemann 1 2 Raphael Schwiertz1 Corinna Grasemann1 Udo Vester1 Kurt Racké3 and Felix Ratjen1 2 Address Children s Hospital University of Duisburg-Essen Essen Germany 2The Hospital for Sick Children University of Toronto Toronto ON Canada and institute for Pharmacology and Toxicology University of Bonn Germany Email Hartmut Grasemann - Raphael Schwiertz - estrich@ Corinna Grasemann - coberste@ Udo Vester - Kurt Racké - Felix Ratjen - Corresponding author Published 09 June 2006 Received 27 January 2006 Respiratory Research 2006 7 87 doi 1465-9921 -7-87 Accepted 09 June 2006 This article is available from http content 7 1 87 2006 Grasemann et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background L-arginine is the common substrate for nitric oxide synthases and arginases. Increased arginase levels in the blood of patients with cystic fibrosis may result in L-arginine deficiency and thereby contribute to low airway nitric oxide formation and impaired pulmonary function. Methods Plasma amino acid and arginase levels were studied in ten patients with cystic fibrosis before and after 14 days of antibiotic treatment for pulmonary exacerbation. Patients were compared to ten healthy non-smoking controls. Results Systemic arginase levels measured by ELISA were significantly increased in cystic fibrosis with exacerbation compared to controls .