tailieunhanh - Báo cáo khoa học: Applications and trends in systems biology in biochemistry

Systems biology has received an ever increasing interest during the last decade. A large amount of third-party funding is spent on this topic, which involves quantitative experimentation integrated with computational modeling. Industrial companies are also starting to use this approach more and more often, especially in pharmaceutical research and biotechnology. | IFEBS Journal REVIEW ARTICLE Applications and trends in systems biology in biochemistry Katrin Hubner Sven Sahle and Ursula Kummer Department of Modeling of BiologicalProcesses COS Heidelberg BioQuant University of Heidelberg Germany Keywords metabolism modeling quantitative experiments signaling simulation systems biology Correspondence U. Kummer Department of Modeling of Biological Processes COS Heidelberg BioQuant University of Heidelberg Im Neuenheimer Feld 267 69120 Heidelberg Germany Fax 49 6221 5451483 E-mail . Received 10 January 2011 revised 31 May 2011 accepted 15 June 2011 doi Systems biology has received an ever increasing interest during the last decade. A large amount of third-party funding is spent on this topic which involves quantitative experimentation integrated with computational modeling. Industrial companies are also starting to use this approach more and more often especially in pharmaceutical research and biotechnology. This leads to the question of whether such interest is wisely invested and whether there are success stories to be told for basic science and or technol-ogy biomedicine. In this review we focus on the application of systems biology approaches that have been employed to shed light on both biochemical functions and previously unknown mechanisms. We point out which computational and experimental methods are employed most frequently and which trends in systems biology research can be observed. Finally we discuss some problems that we have encountered in publications in the field. Introduction One of the fastest growing fields in the life sciences is systems biology. PubMed lists more than 3000 articles which in one way or the other use this term in their title or abstract during the last decade precisely the last 11 years including the year 2000 compared to a mere three articles in the preceding century. Obviously this is partially a result of the fact that