tailieunhanh - Báo cáo y học: " Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations. | Respiratory Research BioMed Central Review Open Access Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations Maria Tsoumakidou1 2 and Nikolaos M Siafakas 1 Address Department of Thoracic Medicine Medical School University of Crete Greece and 2Lung Pathology Unit Department of Gene Therapy National Heart Lung Institute Imperial College London UK Email Maria Tsoumakidou - tsoumak@ Nikolaos M Siafakas - pneumon@ Corresponding author Published 22 May 2006 Received 07 February 2006 Respiratory Research 2006 7 80 doi 1465-9921 -7-80 Accepted 22 May 2006 This article is available from http content 7 1 80 2006 Tsoumakidou and Siafakas licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Airway inflammation increases during acute exacerbations of COPD. Extrinsic factors such as airway infections increased air pollution and intrinsic factors such as increased oxidative stress and altered immunity may contribute to this increase. The evidence for this and the potential mechanisms by which various aetiological agents increase inflammation during COPD exacerbations is reviewed. The pathophysiologic consequences of increased airway inflammation during COPD exacerbations are also discussed. This review aims to establish a cause and effect relationship between etiological factors of increased airway inflammation and COPD exacerbations based on recently published data. Although it can be speculated that reducing inflammation may prevent and or treat COPD exacerbations the existing anti-inflammatory treatments are modestly effective. Background Exacerbations are a cardinal feature of the natural history of moderate and severe .