tailieunhanh - Báo cáo y học: " Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:: " Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure. | Respiratory Research BioMed Central Research Open Access Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure Gurpreet K Singhera1 Tiffany S Chan1 Jenny Y Cheng1 Timothy Z Vitalis2 Kimm J Hamann3 and Delbert R Dorscheid 1 Address The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research Critical Care Group St. Paul s Hospital University of British Columbia Vancouver British Columbia V6Z-1Y6 Canada 2Michael Smith Laboratories 2185 East Mall Vancouver BC V6T 1Z4 Canada and 3Section of Pulmonary and Critical Care Medicine University of Chicago Chicago IL Zip Code 60637 USA Email Gurpreet K Singhera - Gsinghera@ Tiffany S Chan - tc@ Jenny Y Cheng - jyc@ Timothy Z Vitalis - Tvitalis@ Kimm J Hamann - khamann@ Delbert R Dorscheid - Ddorscheid@ Corresponding author Published 18 May 2006 Received 06 October 2005 Respiratory Research 2006 7 78 doi 1465-9921 -7-78 Accepted 18 May 2006 This article is available from http content 7 1 78 2006 Singhera et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Effects of respiratory viral infection on airway epithelium include airway hyper-responsiveness and inflammation. Both features may contribute to the development of asthma. Excessive damage and loss of epithelial cells are characteristic in asthma and may result from viral infection. Objective To investigate apoptosis in Adenoviral-infected Guinea pigs and determine the role of death receptor and ligand expression in the airway epithelial response to limit viral infection. Methods Animal models included both an