tailieunhanh - Báo cáo y học: " Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study. | Respiratory Research BioMed Central Open Access Contribution of alpha- and beta-defensins to lung function decline and infection in smokers an association study Alison M Wallace1 Jian-Qing He1 Kelly M Burkett1 Jian Ruan1 John E Connett2 Nicholas R Anthonisen3 Peter D Paré1 and Andrew J Sandford 1 Address 1James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research University of British Columbia Vancouver Canada 2Division of Biostatistics School of Public Health University of Minnesota Minneapolis USA and 3Faculty of Medicine University of Manitoba Winnipeg Canada Email Alison M Wallace - aw2264@ Jian-Qing He - jhe@ Kelly M Burkett - kburkett@ Jian Ruan - jruan@ John E Connett - john-c@ Nicholas R Anthonisen - nanthonisen@ Peter D Paré - ppare@ Andrew J Sandford - asandford@ Corresponding author Published 15 May 2006 Received 24 October 2005 Respiratory Research 2006 7 76 doi 1465-9921 -7-76 Accepted 15 May 2006 This article is available from http content 7 1 76 2006 Wallace et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Alpha-defensins which are major constituents of neutrophil azurophilic granules and beta-defensins which are expressed in airway epithelial cells could contribute to the pathogenesis of chronic obstructive pulmonary disease by amplifying cigarette smoke-induced and infection-induced inflammatory reactions leading to lung injury. In Japanese and Chinese populations two different beta-defensin-1 polymorphisms have been associated with chronic obstructive pulmonary disease