tailieunhanh - Báo cáo khoa học: Vesicular traffic in cell navigation

Cell navigation is the process whereby cells or cytoplasmic extensions are guided from one point to another in multicellular organisms or, in the case of unicellular eukaryotic organisms, in the environment. Recent work has demonstrated that membrane trafficking plays an important role in this process. | fFEBS Journal REVIEW ARTICLE Vesicular traffic in cell navigation Kathleen Zylbersztejn1 2 and Thierry Galli1 2 1 Membrane Traffic in Neuronal EpithelialMorphogenesis INSERM ERL U950 Paris France 2 Program in Development Neurobiology Institut Jacques Monod CNRS UMR 7592 Paris Diderot University Paris France Keywords axon guidance axon outgrowth epithelial migration SNAREs vesicular traffic Correspondence T. Galli Institut Jacques Monod Bat. Buffon 15 rue Helene Brion 75205 Paris Cedex 13 France Fax 33 157 278 036 Tel 33 157 278 039 E-mail Website http site insermu950 Received 17 February 2011 revised 22 April 2011 accepted 6 May 2011 Cell navigation is the process whereby cells or cytoplasmic extensions are guided from one point to another in multicellular organisms or in the case of unicellular eukaryotic organisms in the environment. Recent work has demonstrated that membrane trafficking plays an important role in this process. Here we review the role of soluble N-ethylmaleimide-sensitive fusion attachment protein SNAP receptors SNAREs which constitute the core machinery for membrane fusion and are essential for intracellular vesicular trafficking. We discuss the important functions of several vesicular- and target-SNAREs in particular vesicular-associated membrane proteins 1 2 3 4 and 7 vti1a b SNAP23 and SNAP25 and syntaxins 1 3 6 and 13. We conclude that endosomal SNAREs are important for cell navigation a concept that opens avenues for fundamental research. There are also possible therapeutic applications because some of these SNAREs are the targets of clostridial neurotoxins. doi Cell navigation Cell navigation is an important process not only during both development and adulthood in metazoans but also during chemotaxis in protozoans. When they are developing cells proliferate in defined areas and often migrate towards others where they fully differentiate. In adults numerous cell .