tailieunhanh - Báo cáo khoa học: Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis

Snake venoms are cocktails of enzymes and non-enzymatic proteins used for both the immobilization and digestion of prey. The most common snake venom enzymes include acetylcholinesterases, L-amino acid oxidases, serine proteinases, metalloproteinases and phospholipases A2 | IFEBS Journal REVIEW ARTICLE Enzymatic toxins from snake venom structural characterization and mechanism of catalysis Tse Siang Kang1 Dessislava Georgieva2 Nikolay Genov3 Mario T. Murakami4 Mau Sinha5 Ramasamy P. Kumar5 Punit Kaur5 Sanjit Kumar5 Sharmistha Dey5 Sujata Sharma5 Alice Vrielink6 Christian Betzel2 Soichi Takeda7 Raghuvir K. Arni8 Tej P. Singh5 and R. Manjunatha Kini9 1 Department of Pharmacy National university of Singapore Singapore 2 Institute of Biochemistry and Molecular Biology University of Hamburg Laboratory of StructuralBiology of Infection and Inflammation Germany 3 Institute of Organic Chemistry Bulgarian Academy of Sciences Sofia Bulgaria 4 NationalLaboratory for Biosciences NationalCenter for Research in Energy and Materials Campinas Brazil 5 Department of Biophysics All India Institute of MedicalSciences New Delhi India 6 Schoolof Biomedical Biomolecular and ChemicalSciences University of Western Australia Crawley Australia 7 NationalCerebraland Cardiovascular Center Research Institute Suita Osaka Japan 8 Department of Physics Centro Multiusuario de Inovacao Biomolecular Sao Paulo State University Scio Jose do Rio Preto Brazil 9 Department of BiologicalSciences Protein Science Laboratory National university of Singapore Singapore Keywords acetylcholinesterase L-amino acid oxidase metalloproteinase phospholipase A2 serine proteinase Correspondence R. M. Kini Protein Science Laboratory Department of Biological Sciences National University of Singapore 14 Science Drive 4 Block S3 03-17 Singapore 117543 Singapore Fax 65 6516 5235 Tel 65 6779 2486 E-mail dbskinim@ Received 2 March 2011 accepted 4 April 2011 Snake venoms are cocktails of enzymes and non-enzymatic proteins used for both the immobilization and digestion of prey. The most common snake venom enzymes include acetylcholinesterases L-amino acid oxidases serine proteinases metalloproteinases and phospholipases A2. Higher catalytic efficiency thermal stability and resistance to

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