tailieunhanh - Báo cáo y học: " Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. | Respiratory Research BioMed Central Research Open Access Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway Matthias Wjst 1 Janine Altmuller1 Theresia Faus-Kessler2 Christine Braig1 Margret Bahnweg1 and Elisabeth André1 Address 1Institut fur Epidemiologie GSF - Forschungszentrum fur Umwelt und Gesundheit Ingolstadter Landstrasse 1 Neuherberg Munich Germany and 2Institut fur Experimentelle Genetik GSF - Forschungszentrum fur Umwelt und Gesundheit Ingolstadter Landstrasse 1 Neuherberg Munich Germany Email Matthias Wjst - wjst@ Janine Altmuller - j@ Theresia Faus-Kessler - faus@ Christine Braig - Margret Bahnweg - Elisabeth André - Corresponding author Published 06 April 2006 Received 23 December 2005 Respiratory Research 2006 7 60 doi 1465-9921 -7-60 Accepted 06 April 2006 This article is available from http content 7 1 60 2006 Wjst et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The vitamin D prophylaxis of rickets in pregnant women and newborns may play a role in early allergic sensitization. We now asked if an already diseased population may have inherited genetic variants in the vitamin D turnover or signalling pathway. Serum levels of calcidiol 25-OH-D3 and calcitriol 1 25- OH 2-D3 were retrospectively assessed in 872 partipants of the German Asthma Family Study. 96 DNA single base variants in 13 different genes were genotyped with MALDI-TOF and a bead array system. At least one positive SNP with a TDT of p for asthma or total IgE and calcidiol or calcitriol was seen in IL10 GC IL12B CYP2R1 IL4R and CYP24A1. .