tailieunhanh - Báo cáo y học: " Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. | Respiratory Research BioMed Central Research Open Access Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice Robert Ten Broeke 1 2 Rini De Crom3 4 Rien Van Haperen3 Vivienne Verweij1 Thea Leusink-Muis1 Ingrid Van Ark1 Fred De Clerck1 5 Frans P Nijkamp1 and Gert Folkerts1 Address Department of Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences Utrecht University . Box 3508 TB Utrecht The Netherlands 2St Antonius Hospital Nieuwegein The Netherlands 3Department of Cell Biology Genetics Erasmus Medical Centre Rotterdam The Netherlands 4Department of Vascular Surgery Erasmus Medical Centre Rotterdam The Netherlands and 5Janssen Research Foundation Beerse Belgium Email Robert Ten Broeke - rtenbroeke@ Rini De Crom - Rien Van Haperen - Vivienne Verweij- Thea Leusink-Muis - Ingrid Van Ark - Fred De Clerck - Frans P Nijkamp - Gert Folkerts - Corresponding author Published 05 April 2006 Received 03 January 2006 Respiratory Research2006 7 58 doi 1465-9921 -7-58 Accepted 05 April 2006 This article is available from http content 7 1 58 2006Broeke et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Asthma is associated with airway hyperresponsiveness and enhanced T-cell number activity on one hand and increased levels of exhaled nitric oxide NO with expression of inducible NO synthase iNOS on the other hand. These findings are in paradox as NO also relaxes airway smooth muscle and has immunosuppressive properties. .