tailieunhanh - Báo cáo y học: "Decrease in the incidence of total hip arthroplasties in patients with rheumatoid arthritis - results from a well defined population in south Sweden"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Decrease in the incidence of total hip arthroplasties in patients with rheumatoid arthritis - results from a well defined population in south Sweden. | Hekmat et al. Arthritis Research Therapy 2011 13 R67 http content 13 2 R67 RESEARCH ARTICLE Open Access Decrease in the incidence of total hip arthroplasties in patients with rheumatoid arthritis - results from a well defined population in south Sweden 1 1 1 2 2 3 Korosh Hekmat Lennart Jacobsson Jan-Ake Nilsson Ingemar F Petersson Otto Robertsson Goran Garellick and Carl Turesson 1 Abstract Introduction One aim of modern pharmacologic treatment in rheumatoid arthritis RA is to prevent joint destruction and reduce the need for surgery. Our purpose was to investigate secular trends in the incidence of primary total hip and knee arthroplasties in a well defined sample of patients with RA. Methods Prevalent cases with RA in 1997 and incident cases from 1997 to 2007 in a community based register in Malmo south Sweden were included. Based on a structured review of the medical records patients were classified according to the 1987 ACR criteria for RA. This cohort was linked to the Swedish Hip Arthroplasty Register through December 2006 and the Swedish Knee Arthroplasty Register through October 2007 . Patients with a registered total hip or knee arthroplasty before 1997 or before RA diagnosis were excluded. Incidence rates for the period of introduction of TNF inhibitors 1998 to 2001 were compared to the period when biologics were part of the established treatment for severe RA 2002 to 2006 2007 . Results In the cohort n 2 164 71 women a primary hip arthroplasty was registered for 115 patients and a primary knee arthroplasty for 82 patients. The incidence of primary total hip arthroplasties decreased from the period 1998 to 2001 1 000 person-years pyr to 2002 to 2006 1 000 pyr rate ratio RR 95 confidence interval CI to . There was a trend towards an increase of primary knee arthroplasties incidence 1 000 pyr vs. 1 000 pyr RR 95 CI to . Conclusions Our investigation shows a significant decrease in the .