tailieunhanh - Báo cáo y học: "Hyperuricemia and the risk for subclinical coronary atherosclerosis - data from a prospective observational cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hyperuricemia and the risk for subclinical coronary atherosclerosis - data from a prospective observational cohort study. | Krishnan et al. Arthritis Research Therapy 2011 13 R66 http content 13 2 R66 RESEARCH ARTICLE Open Access Hyperuricemia and the risk for subclinical coronary atherosclerosis - data from a prospective observational cohort study Eswar Krishnan1 BhavikJ Pandya2 Lorinda Chung1 and Omar Dabbous2 Abstract Introduction Our purpose was to test the hypothesis that hyperuricemia is associated with coronary artery calcification CAC among a relatively healthy population and that the extent of calcification is directly proportional to the serum uric acid sUA concentration. Methods Data from 2 498 participants in the Coronary Artery Risk Development in Young Adults CARDIA study were analyzed using logistic regression models. Subjects were free of clinical heart disease diabetes and renal impairment. The main measure was the presence of any CAC by computerized tomography Agatston score 0 . Results Forty-eight percent of the study participants were male and 45 were African-American. Mean SD age was 40 4 years body mass index 28 6 kg m2 Framingham risk score 5 blood pressure 113 14 75 11 mmHg alcohol consumption 12 27 ml day and sUA 297 89 gmol L mg dL . Prevalence of CAC increased with sUA concentration among both men and women. Adjusted for age gender race lipoproteins triglycerides smoking blood pressure presence of metabolic syndrome C-reactive protein waist circumference alcohol use creatinine and serum albumin the highest quartile of sUA 393 gmol L mg dL for men and 274 gmol L mg dL for women was associated with an odds ratio of compared to the lowest quartile 291 gmol L mg dL for men and 196 gmol L mg dL for women . Among those with any CAC each unit increase in sUA was associated with a 22 increase in Agatston score P after adjusting for the above covariates. Conclusions Hyperuricemia is an independent risk factor for subclinical atherosclerosis in young adults. Introduction Although the link between .