tailieunhanh - Báo cáo y học: " Arsenic trioxide, a potent inhibitor of NF-κB, abrogates allergen-induced airway hyperresponsiveness and inflammation"

Tham khảo luận văn - đề án 'báo cáo y học: " arsenic trioxide, a potent inhibitor of nf-κb, abrogates allergen-induced airway hyperresponsiveness and inflammation"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | BioMed Central Respiratory Research Research Open Access Arsenic trioxide a potent inhibitor of NF-kB abrogates allergen-induced airway hyperresponsiveness and inflammation Lin-Fu Zhou 1 2 3 Yi Zhu1 Xue-Fan Cui1 Wei-Ping Xie1 Ai-Hua Hu3 and Kai-Sheng Yin 1 Address Department of Respiratory Medicine The First Affiliated Hospital Nanjing Medical University Nanjing China 2Global Health Programs University of Pennsylvania School of Medicine Philadelphia USA and 3Division of Pulmonary Medicine Joseph Stokes Jr. Research Institute The Children s Hospital of Philadelphia University of Pennsylvania School of Medicine Philadelphia USA Email Lin-Fu Zhou - lfzhou@ Yi Zhu - zhuyi2000@ Xue-Fan Cui - xuefancui@ Wei- Ping Xie - wpxie@ Ai-Hua Hu - hua@ Kai-Sheng Yin - yinks@ Corresponding authors Published 20 December 2006 Received 19 July 2006 Accepted 20 December 2006 Respiratory Research 2006 7 146 doi 1465-9921-7-146 This article is available from http content 7 1 146 2006 Zhou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Overactivation of nuclear factor kB NF-kB orchestrates airway eosinophilia but does not dampen airway hyperresponsiveness in asthma. NF-kB repression by arsenic trioxide As2O3 contributes to apoptosis of eosinophils EOS in airways. Here we provide evidence that As2O3 abrogates allergen OVA -induced airway eosinophilia by modulating the expression of IkBo. an NF-kB inhibitory protein and decreases the airway hyperresponsiveness. Methods Using a murine model of asthma the airway hyperresponsiveness was conducted by barometric whole-body plethysmography. Airway eosinophilia OVA-specific IgE in .