tailieunhanh - Báo cáo y học: "Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden. | Eriksson et al. Arthritis Research Therapy 2011 13 R30 http content 13 1 R30 RESEARCH ARTICLE Open Access Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden Catharina Eriksson1 Heidi Kokkonen2 Martin Johansson2 Goran Hallmans3 Goran Wadell4 and Solbritt Rantapaa-Dahlqvist2 Abstract Introduction Autoantibodies have a central role in systemic lupus erythematosus SLE . The presence of autoantibodies preceding disease onset by years has been reported both in patients with SLE and in those with rheumatoid arthritis suggesting a gradual development of these diseases. Therefore we sought to identify autoantibodies in a northern European population predating the onset of symptoms of SLE and their relationship to presenting symptoms. Methods The register of patients fulfilling the American College of Rheumatology criteria for SLE and with a given date of the onset of symptoms was coanalysed with the register of the Medical Biobank Umeâ Sweden. Thirtyeight patients were identified as having donated blood samples prior to symptom onset. A nested case-control study 1 4 was performed with 152 age- and sex-matched controls identified from within the Medical Biobank register Umeâ Sweden . Antibodies against anti-Sjogren s syndrome antigen A Ro SSA 52 and 60 kDa antiSjogren s syndrome antigen B anti-Smith antibody ribonucleoprotein scleroderma anti-histidyl-tRNA synthetase antibody double-stranded DNA dsDNA centromere protein B and histones were analysed using the AtheNA Multi-Lyte ANA II Plus Test System on a Bio-Plex Array Reader Luminex200 . Antinuclear antibodies test II ANA II results were analysed using indirect immunofluorescence on human epidermal 2 cells at a sample dilution of 1 100. Results Autoantibodies against nuclear antigens were detected a mean SD of years before the onset of symptoms and years before diagnosis in 63 of the individuals who subsequently developed SLE. The sensitivity was .

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