tailieunhanh - Báo cáo khoa hoc : The ins and outs of pertussis toxin

Pertussis toxin, produced and secreted by the whooping cough agent Bordetella pertussis, is one of the most complex soluble bacterial proteins. It is actively secreted through the B. pertussiscell envelope by the Ptl secretion system, a member of the widespread type IV secretion systems. | IFEBS Journal REVIEW ARTICLE The ins and outs of pertussis toxin Camille Locht Loic Coutte and Nathalie Mielcarek Inserm U1019 CNRS UMR8204 Center for Infection and Immunity of Lille Institut Pasteur de Lille Univ Lille Nord de France France Keywords A-B toxins ADP-ribosylation retrograde transport type IV secretion system whooping cough Correspondence C. Locht Inserm U1019 CNRS UMR8204 Center for Infection and Immunity of Lille Institut Pasteur de Lille Univ Lille Nord de France 1 rue du Prof. Calmette F-59019 Lille Cedex France Fax 33 3 20 87 11 58 Tel 33 3 20 87 11 51 E-mail Received 5 April 2011 revised 14 June 2011 accepted 20 June 2011 Pertussis toxin produced and secreted by the whooping cough agent Bordetella pertussis is one of the most complex soluble bacterial proteins. It is actively secreted through the B. pertussis cell envelope by the Ptl secretion system a member of the widespread type IV secretion systems. The toxin is composed of five subunits named S1 to S5 according to their decreasing molecular weights arranged in an A-B structure. The A protomer is composed of the enzymatically active S1 subunit which catalyzes ADP-ribosyla-tion of the a subunit of trimeric G proteins thereby disturbing the metabolic functions of the target cells leading to a variety of biological activities. The B oligomer is composed of 1S2 1S3 2S4 1S5 and is responsible for binding of the toxin to the target cell receptors and for intracellular trafficking via receptor-mediated endocytosis and retrograde transport. The toxin is one of the most important virulence factors of B. pertussis and is a component of all current vaccines against whooping cough. doi Introduction As a multimeric 105 kDa protein pertussis toxin PTX is one of the most complex bacterial protein toxins known to date. It is composed of five different subunits named S1 to S5 according to their decreasing molecular weights and is exclusively .

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