tailieunhanh - Báo cáo y học: " Abnormalities of T cell signaling in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Abnormalities of T cell signaling in systemic lupus erythematosus. | Moulton and Tsokos Arthritis Research Therapy 2011 13 207 http content 13 2 207 REVIEW Abnormalities of T cell signaling in systemic lupus erythematosus Vaishali R Moulton and George C Tsokos Abstract Systemic lupus erythematosus SLE is an autoimmune disease resulting from a loss of tolerance to multiple self antigens and characterized by autoantibody production and inflammatory cell infiltration in target organs such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues leading to tissue damage. Abnormal signaling events link to defective gene transcription and altered cytokine production contributing to the aberrant phenotype of T cells in SLE. Study of signaling and gene transcription abnormalities in SLE T cells has led to the identification of novel targets for therapy. Introduction T cells and systemic lupus erythematosus Systemic lupus erythematosus SLE is an autoimmune disease that afflicts mainly women in the reproductive years. It is a multisystem disease affecting the joints skin kidneys and brain and is characterized by autoantibody production by dysregulated B cells target organ infiltration by inflammatory T cells and aberrant immune cell activation due to abnormal antigen presenting cell APC function. While aberrant T cells provide help to autoreactive B cells they also infiltrate target organs causing damage and thus are key players in SLE disease pathogenesis. Understanding the underlying defects within T lymphocytes is of utmost importance not only for understanding disease pathophysiology but also for identifying predictive biomarkers and better therapeutic targets. T lymphocytes from SLE patients are unique in that they resemble naive or somewhat anergic T cells in certain ways such as their reduced ability to produce cytokines like interferon-y and IL2 but simultaneously Correspondence vmoulton@ Division of .