tailieunhanh - Báo cáo y học: "Predictors for pathologically confirmed aortitis after resection of the ascending aorta: A 12-year Danish nationwide population-based cross-sectional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Predictors for pathologically confirmed aortitis after resection of the ascending aorta: A 12-year Danish nationwide population-based cross-sectional study. | Schmidt et al. Arthritis Research Therapy 2011 13 R87 http content 13 3 R87 RESEARCH ARTICLE Open Access Predictors for pathologically confirmed aortitis after resection of the ascending aorta A 12-year Danish nationwide population-based cross-sectional study Jean Schmidt1 2 Kaare Sunesen1 Jette B Kornum1 Pierre Duhaut2 and Reimar W Thomsen1 Abstract Introduction Assessing the prevalence of and predictors for pathologically-confirmed inflammation of the aorta in Denmark using a nationwide population-based study design. Methods We identified all adults with first-time surgery on the ascending aorta between January 1 1997 and March 1 2009 in Denmark. Presence of aortic inflammation was ascertained through linkage to a nationwide pathology registry. We used logistic regression to compute prevalence odds ratios ORs for sex age at surgery cardiovascular risk factors cancer connective tissue disease and infectious diseases associated with the presence of aortitis. Results A total of 1 210 adults underwent resection of the ascending aorta of who 610 had tissue submitted for pathological examination. Aortitis was found in 37 patients whose tissue was examined. Ten of the 37 patients were diagnosed with conditions known to be associated with aortitis or aortic aneurysm five patients with temporal arteritis one with Crohn s disease one with rheumatoid arthritis one with systemic lupus erythematosus one with infectious aortitis and one with Marfan s disease. Twenty-seven patients had idiopathic aortitis. Predictors of aortitis included history of connective tissue disease adjusted OR 95 confidence interval CI diabetes OR 95 CI advanced age 67 years OR 95 CI and aortic valve pathology OR 95 CI . Conclusions Aortitis was present in of adults in Denmark who had pathological examination after resection of the ascending aorta. Predictors of inflammation included connective tissue disease diabetes