tailieunhanh - Báo cáo y học: " Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. | Respiratory Research BioMed Central Research Open Access Toll-like receptors in cellular subsets of human tonsil T cells altered expression during recurrent tonsillitis Anne Mansson Mikael Adner and Lars Olaf Cardell Address Laboratory of Clinical and Experimental Allergy Research Department of Otorhinolaryngology Malmo University Hospital Lund University 205 02 Malmo Sweden Email Anne Mansson - Mikael Adner - Lars Olaf Cardell - Corresponding author Published 27 February 2006 Received 04 October 2005 Respiratory Research 2006 7 36 doi 1465-9921-7-36 Accepted 27 February 2006 This article is available from http content 7 1 36 2006 Mnsson et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The palatine tonsils have a pivotal role in immunological detection of airborne and ingested antigens like bacteria and viruses. They have recently been demonstrated to express Tolllike receptors TLRs known to recognize molecular structures on such microbes and activate innate immune responses. Their activation might also provide a link between innate and adaptive immunity. In the present study the expression profile of TLR1-TLR10 was characterized in human tonsil T cells focusing on differences between subsets of CD4 T helper Th cells and CD8 cytotoxic T lymphocytes CTL . The study was also designed to compare the TLR expression in T cells from patients with recurrent tonsillitis and tonsillar hyperplasia. Methods Tonsils were obtained from children undergoing tonsillectomy and classified according to the clinical diagnoses and the outcome of tonsillar core culture tests. Two groups were defined recurrently .