tailieunhanh - Báo cáo y học: "Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insig"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. | Ishijima et al. Arthritis Research Therapy 2011 13 R22 http content 13 1 R22 RESEARCH ARTICLE Open Access Relationships between biomarkers of cartilage bone synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis h I I I zs-sl i I r p I I I V VX X 1 2 3 t I I I I A s 4- s izi 1 4 51 IXA r s I ỈF l I - i t- - 4 5 t I_I I I I lx s IX 1 2 I L I Cl 14 X m I 1 2 LX S u- I r I m I IK S I f p i r-1- 6 MuneaKi Isnijima Idiji Wdidii Kiyohito Naito naruKa KaneKo Ippei rutami Kaori Yoshimura-Ishida A lx Px I 4- I r ws f X -X X 7 I_I I z J .X Ịf- 7 X L-v-x X z i I I Px 16 I x 4 I- I I v m m z xFz x6 I r f l I s z t r lx s 3 4 I_I I I- r Px I IXI I v rm A r- x 2 AKihito lomonaga Hideyo Yamaguchi Tetsuro Yamamoto Isao NagaoKa Hisashi Kurosawa Robin A Poole8 and Kazuo KaneKo1 2 3 Abstract Introduction We tested the hypothesis that there exist relationships between the onset of early stage radiographically defined Knee osteoarthritis OA pain and changes in biomarKers of joint metabolism. Methods Using Kellgren-Lawrence K L grading early radiographic Knee OA K L 2 was detected in 16 of 46 patients. These grades K L 1 is no OA and K L 2 is early OA were divided into two groups according to the presence or absence of persistent Knee pain. Sera s and urines u were analysed with biomarKers for cartilage collagen cleavage sC2C and uCTX-II and synthesis sCPII bone resorption uNTx and synovitis hyaluronic acid sHA . Results sCPII decreased and sC2C sCPII uCTX-II sCPII and sHA increased with onset of OA K L 2 versus K L 1 irrespective of joint pain. In contrast sC2C and uCTX-II remained unchanged in early OA patients. Of the patients with K L grades 1 and 2 sC2C sCPII sHA uNTX and uCTX-II were all significantly increased in patients with Knee pain independent of grade. Among the K L grade 2 subjects only uCTX-II and uCTX-II sCPII were increased in those with Knee pain. In grade 1 patients both sC2C and sCPII were .