tailieunhanh - Báo cáo y học: "Lung fibroblasts from patients with emphysema show markers of senescence in vitro"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " "Lung fibroblasts from patients with emphysema show markers of senescence in vitro. | BioMed Central Respiratory Research Research Open Access Lung fibroblasts from patients with emphysema show markers of senescence in vitro K-C Muller1 2 L Welker1 K Paasch1 B Feindt1 VJ Erpenbeck3 JM Hohlfeld3 N Krug3 M Nakashima1 D Branscheid1 H Magnussen1 RA Jorres1 4 and O Hoiz 1 2 Address Hospital GroKhansdorf Center for Pneumology and Thoracic Surgery D-22927 GroKhansdorf Germany 2University of Luneburg Institute of Environmental Chemistry D-21335 Luneburg Germany 3Fraunhofer Institute of Toxicology and Experimental Medicine Department for Clinical Inhalation D-30625 Hannover Germany and 4Institute and Outpatient Clinic for Occupational and Environmental Medicine Ludwig-Maximilians-University D-80336 Munich Germany Email K-C Muller - L Welker - K Paasch - B Feindt - VJ Erpenbeck - erpenbeck@ JM Hohlfeld - hohlfeld@ N Krug - krug@ M Nakashima - D Branscheid - H Magnussen - magnussen@ RA Jorres - O Holz - Corresponding author Published 21 February 2006 Received II November 2005 Respiratory Research2006 7 32 doi 1465-9921 -7-32 Accepted 21 February 2006 This article is available from http content 7 I 32 2006Muller et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The loss of alveolar walls is a hallmark of emphysema. As fibroblasts play an important role in the maintenance of alveolar structure a change in fibroblast phenotype could be involved in the pathogenesis of this disease.