tailieunhanh - Báo cáo y học: " Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression of potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients. | Bittner et al. Arthritis Research Therapy 2011 13 R21 http content 13 1 R21 RESEARCH ARTICLE Open Access Expression of potassium channels on CD4 T lymphocytes correlates with disease activity in rheumatoid arthritis patients 1 f 2f 3 2 2 Stefan Bittner Nicole Bobak Martin Feuchtenberger Alexander M Herrmann Kerstin Gobel D I m I I Z l A IXỈt t 4 A l r I I I n rT n r D I I Z-J Z X6 p. VI r t Z I lz l ìf r l- f ì f-_71 I 1X f V c rz 7 I Inr r D xh xr I u .X i3 Raimund W Kinne Anker J Hansen Thomas BUdde Christoph Kleinschnitz Oliver Frey Hans-Peter Tony Heinz Wiendl2 Sven G Meuth1 2 6 Abstract Introduction CD4 T cells express TWIK-related acid-sensitive potassium channel 2 TASK2 KCNK5 a member of the two-pore domain potassium channel family which has been shown to influence T cell effector functions. Recently it was shown that is upregulated upon autoimmune T cell stimulation. The aim of this study was to correlate expression levels of on T cells from patients with rheumatoid arthritis RA to disease activity in these patients. Methods Expression levels of were measured by RT-PCR in the peripheral blood of 58 patients with RA and correlated with disease activity parameters C-reactive protein levels erythrocyte sedimentation rates disease activity score DAS28 scores . Twenty patients undergoing therapy change were followed-up for six months. Additionally synovial fluid and synovial biopsies were investigated for T lymphocytes expressing . Results expression levels in CD4 T cells show a strong correlation to DAS28 scores in RA patients. Similar correlations were found for serological inflammatory parameters erythrocyte sedimentation rate C-reactive protein . In addition expression levels of synovial fluid-derived T cells are higher compared to peripheral blood T cells. Prospective data in individual patients show a parallel behaviour of expression to disease activity parameters during a