tailieunhanh - Báo cáo y học: " Pulmonary vasoconstrictor action of KCNQ potassium channel blockers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Pulmonary vasoconstrictor action of KCNQ potassium channel blockers. | Respiratory Research BioMed Central Research Open Access Pulmonary vasoconstrictor action of KCNQ potassium channel blockers Shreena Joshi1 2 Prabhu Balan1 and Alison M Gurney 1 2 Address department of Physiology Pharmacology University of Strathclyde 27 Taylor street Glasgow G4 0NR UK and 2Faculty of Life Sciences University of Manchester Floor 2 Core Technology Facility University of Manchester 46 Grafton Street Manchester M13 9NT UK Email Shreena Joshi - Prabhu Balan - Alison M Gurney - Corresponding author Published 20 February 2006 Respiratory Research 2006 7 31 doi l465-992l -7-31 Received 0l November 2005 Accepted 20 February 2006 This article is available from http content 7 l 3 l 2006 Joshi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background KCNQ channels have been widely studied in the nervous system heart and inner ear where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence spontaneous contractile activity. The biophysical properties of K currents mediated by KCNQ channels resemble a current underlying the resting K conductance and resting potential of pulmonary artery smooth muscle cells. We therefore investigated a possible role of KCNQ channels in regulating the function of pulmonary arteries by determining the ability of the selective KCNQ channel blockers linopirdine and XE99l to promote pulmonary vasoconstriction. Methods The tension developed by rat and mouse intrapulmonary or mesenteric arteries was measured using small vessel myography. .

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