tailieunhanh - Báo cáo y học: "The usefulness of magnetic resonance imaging of the hand and wrist in very early rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The usefulness of magnetic resonance imaging of the hand and wrist in very early rheumatoid arthritis. | Kosta et al. Arthritis Research Therapy 2011 13 R84 http content 13 3 R84 RESEARCH ARTICLE Open Access The usefulness of magnetic resonance imaging of the hand and wrist in very early rheumatoid arthritis 1 2 1 2 1 Paraskevi E Kosta Paraskevi V Voulgari Anastasia K Zikou Alexandros A Drosos and Maria I Argyropoulou Abstract Introduction Magnetic resonance imaging MRI was used to study the hand and wrist in very early rheumatoid arthritis RA and the results were compared with early and established disease. Methods Fifty-seven patients fulfilling the new American College of Rheumatology criteria for RA 26 with very early RA VERA 18 with early RA ERA and 13 with established RA ESTRA disease duration 3 months 12 months and 12 months respectively were enrolled in the study. MRI of the dominant hand and wrist was performed by using fat-suppressed T2-weighted and plain and contrast-enhanced T1-weighted sequences. Evaluation of bone marrow edema synovitis and bone erosions was performed with the OMERACT RA MRI scoring system. Results Edema erosions and synovitis were present in VERA and the prevalence was 100 and respectively. Significant differences in edema and erosions were found between VERA and ESTRA P . No significant difference was found in synovitis. Conclusions Edema erosions and synovitis are findings of very early RA. MRI by detecting these lesions may play an important role in the management of these patients. Introduction Rheumatoid arthritis RA is a chronic systemic inflammatory disease characterized by prominent joint manifestations. Inflammation of the synovial membrane leads to the formation of a highly cellular inflammatory tissue the pannus which by eroding cartilage and bone leads to joint destruction and ankylosis 1 . Articular involvement of the hand and wrist has been considered a very frequent presenting finding 1 . The presence of marginal erosions seen on conventional radiographs of the hand and wrist has .