tailieunhanh - Báo cáo y học: " Diagnostic properties of metabolic perturbations in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Diagnostic properties of metabolic perturbations in rheumatoid arthritis. | Madsen et al. Arthritis Research Therapy 2011 13 R19 http content 13 1 R19 RESEARCH ARTICLE Open Access Diagnostic properties of metabolic perturbations in rheumatoid arthritis D r m I I r IX IV I r 1 I z . r I I MV S I f 2 3 I Z S. í 1 r I T-d r c r 3 r I I rz 4 í r r IV I K I S A I - t-. i I I r 5 Rasmus K Madsen lorojorn Lundsted Jon Gabrielsson Carl-Johan Sennbro Gerd-Marie Alenius Thomas Moritz6 Solbritt Rantapaa-Dahlqvist5 Johan Trygg1 Abstract Introduction The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis RA by measuring selected metabolic biomarkers. Methods We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis PsoA . The metabolites were measured using two different chromatography-mass spectrometry platforms thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results RA patients were diagnosed with a sensitivity of 93 and a specificity of 70 in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90 and a specificity of 94 . Glyceric acid D-ribofuranose and hypoxanthine were increased in RA patients whereas histidine threonic acid methionine cholesterol asparagine and threonine were all decreased compared with healthy controls. Conclusions Metabolite profiling metabolomics is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides. Introduction Rheumatoid arthritis RA is an autoimmune disease in which the synovial tissues of the affected joints are invaded by cells of the immune system 1 2 . Primarily the hands and feet are affected but other joints may be .