tailieunhanh - Báo cáo y học: "IL-17 in spondyloarthritis: is the T-party over"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: IL-17 in spondyloarthritis: is the T-party over? | Yeremenko and Baeten Arthritis Research Therapy 2011 13 115 http content 13 3 115 EDITORIAL L_ IL-17 in spondyloarthritis is the T-party over Nataliya Yeremenko and Dominique Baeten See related research by Appel etal. http content 13 3 R95 Abstract The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17 originally identified as the signature cytokine of a distinct CD4 T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-17 released in inflammatory arthritis is produced by innate immune cells rather than T cells. Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways. Introduction the IL-23 IL-17 axis in spondyloarthritis In the present issue of Arthritis Research Therapy Heiner Appel and colleagues from Berlin present an important histological study on IL-17-producing cells in spondyloarthritis SpA 1 . The IL-23 IL-17 axis has become a major focus of SpA research based on three key observations. Firstly the ankylosing spondylitis subset of SpA is associated with genetic polymorphisms of the IL-23 receptor - the protective R381Q gene variant has recently been demonstrated to impair Th17 responses 2 3 . Secondly the unfolded protein response - a cellular stress programme that can be initiated by HLA-B27 misfolding - strongly increases the production of IL-23 4 . Thirdly a recent proof-of-concept trial with an anti-IL-17A monoclonal antibody showing good efficacy in active ankylosing spondylitis provided the first direct evidence that IL-17 plays an important role in SpA pathogenesis 5 . Identification of IL-17-producing cells The IL-23 IL-17 axis was originally described in T-cell .