tailieunhanh - Báo cáo y học: "Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis. | Li et al. Arthritis Research Therapy 2011 13 R17 http content 13 1 R17 RESEARCH ARTICLE Open Access Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis Dawei Li1 t Yuji Wang1 2 f Nanwei Xu2 Qianghua Wei3 Min Wu4 Xiaofeng Li5 Ping Zheng6 Sai Sun1 Yuli Jin3 Gailian Zhang5 Ruomin Liao7 Ping Zhang8 Abstract Introduction Follistatin-like protein 1 FSTL1 is a proinflammation mediator implicated in arthritis in rodent animal models. The present study is aimed at assessing FSTL1 levels in systemic autoimmune diseases and correlating them with disease activity in patients with rheumatoid arthritis RA . Methods Serum FSTL1 levels from 487 patients with systemic autoimmune diseases and 69 healthy individuals were measured by enzyme-linked immunosorbent assay ELISA . FSTL1 expression in synovial fluid SF and synovial tissues STs was determined by ELISA immunohistochemistry real-time polymerase chain reaction RT-PCR and western blot analysis in RA patients and trauma controls. FSTL1 levels in fibroblast-like synoviocytes FLSs from RA patients were determined by real-time PCR and western blot analysis. Results Serum FSTL1 levels were significantly elevated in patients with RA ulcerative colitis systemic lupus erythematosus Sjogren s syndrome SS systemic sclerosis and polymyositis dermatomyositis. Serum FSTL1 levels in the RA and secondary SS patients were substantially higher than those in other patients. Serum FSTL1 levels were increased in early RA rheumatoid factor RF - and anti-cyclic citrullinated peptide antibody ACPA -negative patients compared to healthy controls. Moreover serum FSTL1 concentrations were significantly higher in longstanding RA patients than in early RA patients and in the RF- and ACPA-positive RA patients than in RF- and ACPA-negative RA patients. Elevated FSTL1 levels in the STs and SF of RA patients were also observed. FSTL1 levels in .