tailieunhanh - Pharmacology and Therapeutics of Cough

The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the pharmacological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the voluntary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons. One group of experimental studies has particular relevance to human patients, and that is the demonstration of the sensitization of cough pathways both in the periphery and in the brainstem | Handbook of Experimental Pharmacology 187 Kian Fan Chung John Widdicombe Editors Pharmacology and Therapeutics ofCough 0 springer Handbook of Experimental Pharmacology Volume 187 Editor-in-Chief F. Hofmann Munchen Editorial Board J. Beavo Seattle WA A. Busch Berlin D. Ganten Berlin . Karlsson Singapore M. Michel Amsterdam . Page London W. Rosenthal Berlin Kian Fan Chung John Widdicombe Editors Pharmacology and Therapeutics of Cough Contributors . Belvisi F. Bertram . Birring . Bolser . Bonham J. Bric . Canning . Carr . Chen . Chou . Chung . Davenport . Dicpinigaitis R. Eccles E. Ernst R. Gatti P. Geppetti Q. Gu . Hele . Joad . Lee S. Materazzi . Mazzone . McAlexander I. M. McFadzean L. McGarvey . Morice R. Nassini . Page . Pavord . Raj T. Shirasaki F. Soeda D. Spina K. Takahama M. Trevisani . Undem J. G. Widdicombe .