tailieunhanh - Báo cáo y học: "Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. | Rossini et al. Arthritis Research Therapy 2010 12 R216 http content 12 6 R216 RESEARCH ARTICLE Open Access Vitamin D deficiency in rheumatoid arthritis prevalence determinants and associations with disease activity and disability Maurizio Rossini1 Susanna Maddali Bongi2 Giovanni La Montagna3 Giovanni Minisola4 Nazzarena Malavolta5 I III z t I D M iM M6 r s r s r 7 I I I I I c I I z t s z t I I s 8 KỲ h1 I I I f 9 c I I ỉ s ws I 1 Luigi Bernini Enrico Cacace Luigi Sinigaglia Ombretta DI Munno Silvano Adami Abstract Introduction The aim of this study was to estimate the prevalence and determinants of vitamin D deficiency in patients with rheumatoid arthritis RA as compared to healthy controls and to analyze the association between 25-hydroxyvitamin D 25 OH D with disease activity and disability. Methods The study includes 1 191 consecutive RA patients 85 women and 1 019 controls not on vitamin D supplements from 22 Italian rheumatology centres. Together with parameters of disease activity functional impairment and mean sun exposure time all patients had serum 25 OH D measured in a centralized laboratory. Results A total of 55 of RA patients were not taking vitamin D supplements the proportion of these with vitamin D deficiency 25 OH D level 20 ng ml was 52 . This proportion was similar to that observed in control subjects . One third of supplemented patients were still vitamin D deficient. In non-supplemented RA patients 25 OH D levels were negatively correlated with the Health Assessment Questionnaire Disability Index Disease Activity Score DAS28 and Mobility Activities of daily living score. Significantly lower 25 OH D values were found in patients not in disease remission or responding poorly to treatment and with the highest Steinbrocker functional state. Body mass index BMI and sun exposure time were good predictors of 25 OH D values P . The association between disease activity or functional scores and 25 OH D levels remained .

TÀI LIỆU LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.