tailieunhanh - HANDBOOK OF PLATELET PHYSIOLOGY AND PHARMACOLOGY

Despite my many years of research and teaching in platelet physiology and pharmacology at the University of Minnesota, I am often confronted with conflicting opinions as to the relevance of nonnucleated platelets in human health and disease. It is fascinating to think that how cells with no apparent nucleus, have such a towering impact on concepts, dealing with often overlapping physiological (. hemostasis, wound healing, etc.) and pathophysiological (. thrombosis, stroke, atherosclerosis, wound healing, diabetes, inflammation and cancer) components. Although the idea of compiling new frontiers of platelet research in the form of a book was quite simple at the beginning, the project turned out to be a. | HANDBOOK OF PLATELET PHYSIOLOGY AND PHARMACOLOGY Edited by Gundu H. R. Rao University of Minnesota KLUWER ACADEMIC PUBLISHERS Boston Dordrecht London Distributors for North Central and South America Kluwer Academic Publishers 101 Philip Drive Assinippi Park Norwell Massachusetts 02061 USA Telephone 781 871-6600 Fax 781 871-6528 E-Mail kluwer@ Distributors for all other countries Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 AH Dordrecht THE NETHERLANDS Telephone 31 78 6392 392 Fax 31 78 6546 474 E-Mail services@ Electronic Services http Library of Congress Cataloging-in-Publication Data Handbook of platelet physiology and pharmacology edited by Gundu . Rao. p. cm. Includes bibliographical references and index. ISBN 0-7923-8538-1 alk. paper 1. Blood platelets Handbooks manuals etc. I. Rao Gundu . 1938- . 1999 99-27962 CIP Copyright 1999 by Kluwer Academic Publishers All rights reserved. No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means mechanical photocopying recording or otherwise without the prior written permission of the publisher Kluwer Academic Publishers 101 Philip Drive Assinippi Park Norwell Massachusetts 02061 Printed on acid-free paper. Printed in the United States of America List of Contributors Kailash c. Agarwal Ph. D. Department of Molecular Pharmacology Brown University Providence RI 02912 USA 7. Robert w. Colman M. D. Thrombosis Research Center Temple Univ. Sch. of Medicine 3400 N. Broad Street Philadelphia PA 19140 USA Colin N. Baigent Ph. D. ATT Collaboration CTSU Harkness Building Radcliffe Infirmary Woodstock Road Oxford 0X2 6HE 8. Maribel Diaz-Ricart Ph. D. Servicio de Hemoterapia Hospital Clinico Provincial Villarroel 170 Barcelona 08036 Spain United Kingdom Rodger L. Bick M. D. Ph. D. Departments of Pathology Pharmacology Loyola University Med. Center 9. Gines Escolar M. D. Ph. D. Servicio