tailieunhanh - Báo cáo y học: "Comparisons of 7- to 78-joint ultrasonography scores: all different joint combinations show equal response to adalimumab treatment in patients with rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Comparisons of 7- to 78-joint ultrasonography scores: all different joint combinations show equal response to adalimumab treatment in patients with rheumatoid arthritis. | Hammer and Kvien Arthritis Research Therapy 2011 13 R78 http content 13 3 R78 RESEARCH ARTICLE Open Access Comparisons of 7- to 78-joint ultrasonography scores all different joint combinations show equal response to adalimumab treatment in patients with rheumatoid arthritis Hilde Berner Hammer and Tore K Kvien Abstract Introduction The primary objectives were to explore the associations between a comprehensive ultrasonographic US assessment of joints tendons and bursae and previously described reduced joint counts 7- 12- 28- and 44-joint score as well as to assess the sensitivity to change of these different US joint combinations during biological treatment. Methods Twenty patients with rheumatoid arthritis RA were examined by US B-mode BM and power Doppler PD with use of a semi-quantitative 0 to 3 score of 78 joints 36 tendons tendon groups and two bursae hereafter described as the 78-joint score at baseline and 1 3 6 and 12 months after initiating treatment with adalimumab. BM and PD scores for the different joint combinations were generated. Results The reduced joint scores had high correlation coefficients with the 78-joint score at all examinations range to for BM and to for PD each P and sum BM and PD scores of all the different joint combinations improved significantly during follow-up P to . Conclusions The reduced joint combinations were highly associated to the 78-joint score. Furthermore all the joint combinations presently explored responded well to biological treatment. This indicates that an approach focusing on few joints and tendons gives equivalent information about the inflammatory activity in RA patients as a comprehensive US examination. The optimal combination of joints and tendons for a valid reliable and feasible US measurement should be further explored to define a US score for follow-up of RA patients on biological treatment. Introduction Ultrasonography US is increasingly used for