tailieunhanh - Báo cáo y học: "Chemerin/ChemR23 pathway: a system beyond chemokines"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Chemerin/ChemR23 pathway: a system beyond chemokines. | lannone and Lapadula Arthritis Research Therapy 2011 13 104 http content 13 2 104 EDITORIAL L_ Chemerin ChemR23 pathway a system beyond chemokines Florenzo lannone and Giovanni Lapadula See related research by Berg etal. http content 12 6 R228 Abstract Chemerin is a ehemokine that through the engagement of its counter-receptor ChemR23 attracts pro-inflammatory cells. However chemerin has been shown to play other functions and a recent study by Berg and colleagues demonstrates that chemerin ChemR23 is a system beyond chemokines. Human articular chondrocytes produce chemerin and express ChemR23 and upon stimulation with recombinant chemerin increase the production of pro-catabolic cytokines and metalloproteinases. The latter are up-regulated in osteoarthritic cartilage and cause extracellular matrix breakdown. Since an increase of chemerin in fat tissue and serum of obese patients has been reported this new feature of chemerin may represent a functional link between obesity and osteoarthritis. Knowledge of the pathophysiology of articular cartilage is crucial in understanding the mechanisms underlying joint diseases such as osteoarthritis OA and rheumatoid arthritis RA . In a previous issue of Arthritis Research and Therapy Berg and colleagues 1 have provided new insights in this field by showing for the first time that chondrocytes express chemerin and its cognate receptor ChemR23 and that this system may be involved in cartilage degradation. Chemerin is a secreted protein that exerts its functions by binding the G protein-coupled receptor ChemR23. It was first discovered as a chemotactic peptide directing macrophages and dendritic cells expressing ChemR23 toward sites of inflammation being involved in both adaptive and innate immunity 2 . As often happens regulatory proteins have pleiotropic functions. ChemR23 is also expressed by endothelial cells where it is Correspondence .