tailieunhanh - Báo cáo y học: "Risk factors for ANA positivity in healthy persons"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Risk factors for ANA positivity in healthy persons. | Li et al. Arthritis Research Therapy 2011 13 R38 http content 13 2 R38 RESEARCH ARTICLE Open Access Risk factors for ANA positivity in healthy persons -S 71 I -1 2 I- -S 2 2 1 1 3 Quan-Zhen Li David R Karp Jiexia Quan Valerie K Branch Jinchun Zhou Yun Lian Benjamin F Chong Edward K Wakeland1 and Nancy J Olsen2 4 Abstract Introduction The finding of antinuclear antibody ANA positivity in a healthy individual is usually of unknown significance and in most cases is benign. However a subset of such individuals is at risk for development of autoimmune disease. We examined demographic and immunological features that are associated with ANA positivity in clinically healthy persons to develop insights into when this marker carries risk of progression to lupus. Methods Biological samples from healthy individuals and patients with systemic lupus erythematosus SLE were obtained from the Dallas Regional Autoimmune Disease Registry DRADR . Measurements carried out on serum samples included ANA extractable nuclear antibodies ENA and autoantibody profiling using an array with more than 100 specificities. Whole blood RNA samples from a subset of individuals were used to analyze gene expression on the Illumina platform. Data were analyzed for associations of high ANA levels with demographic features the presence of other autoantibodies and with gene expression profiles. Results Overall ANA levels are significantly higher in females than in males and this association holds in patients with the autoimmune diseases lupus and rheumatoid arthritis RA as well as in healthy controls HC . Age was not significantly associated with ANA levels and the elevated ANA values could not be explained by higher IgG levels. Another autoantibody anti- cyclic citrullinated peptide CCP did not show gender dimorphism in rheumatoid arthritis RA or healthy individuals. The autoantigen array showed significant elevations of other autoantibodies in high ANA HCs. Some of these .