tailieunhanh - Báo cáo y học: " Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Projec"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Project. | Nelson et al. Arthritis Research Therapy 2011 13 R37 http content 13 2 R37 RESEARCH ARTICLE Open Access Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis a cross-sectional analysis in the Johnston County Osteoarthritis Project 1 2 3 14 Amanda E Nelson Xiaoyan A Shi Todd A Schwartz 1 Jiu-Chiuan Chen Jordan B Renner1 Kathleen L Caldwell5 Charles G Helmick5 and Joanne M Jordan1 Abstract Introduction Lead Pb is known to affect bone and recent evidence suggests that it has effects on cartilage as well. As osteoarthritis OA is a highly prevalent disease affecting bone and cartilage we undertook the present analysis to determine whether whole blood Pb levels are associated with radiographic and symptomatic OA rOA and sxOA respectively of the knee. Methods The analysis was conducted using cross-sectional data from the Johnston County Osteoarthritis Project a rural population-based study including whole blood Pb levels bilateral posteroanterior weight-bearing knee radiography and knee symptom data. rOA assessment included joint-based presence Kellgren-Lawrence K-L grade 2 or higher and severity none K-L grade 0 or 1 mild K-L grade 2 moderate or severe K-L grade 3 or 4 as well as person-based laterality unilateral or bilateral . SxOA was deemed present joint-based in a knee on the basis of K-L grade 2 or higher with symptoms with symptoms rated based on severity 0 rOA without symptoms 1 rOA with mild symptoms 2 rOA with moderate or severe symptoms and in person-based analyses was either unilateral or bilateral. Generalized logit or proportional odds regression models were used to examine associations between the knee OA status variables and natural log-transformed blood Pb ln Pb continuously and in quartiles controlling for age race sex body mass index BMI smoking and alcohol drinking. Results Those individuals with whole blood Pb data N 1 669 had a mean SD age of years and a mean BMI of