tailieunhanh - Báo cáo y học: " Recent advances in asthma genetics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Recent advances in asthma genetics. | Respiratory Research BioMed Central Review Recent advances in asthma genetics Jian Zhang Peter D Paré and Andrew J Sandford Open Access Address James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research St. Paul s Hospital Vancouver . V6Z 1Y6 Canada Email Jian Zhang - JZhang1@ Peter D Paré - PPare@ Andrew J Sandford - ASandford@ Corresponding author Published 15 January 2008 Received 15 May 2007 Respiratory Research 2008 9 4 doi l465-992l-9-4 Accepted I5 January 2008 This article is available from http content 9 l 4 2008 Zhang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract There are over 100 genes that have been reported to be associated with asthma or related phenotypes. In 2006-2007 alone there were 53 novel candidate gene associations reported in the literature. Replication of genetic associations and demonstration of a functional mechanism for the associated variants are needed to confirm an asthma susceptibility gene. For most of the candidate genes there is little functional information. In a previous review by Hoffjan et al. published in 2003 functional information was reported for 40 polymorphisms and here we list another 22 genes which have such data. Some important genes such as filaggrin interleukin-13 interleukin-l7 and the cysteinyl leukotriene receptor-l which not only were replicated by independent association studies but also have functional data are reviewed in this article. Background Asthma is a disease of chronic airway inflammation that affects nearly 155 million individuals worldwide 1 2 . Like other atopic diseases asthma is a complex disorder caused by interactions between multiple genes of small to modest .