tailieunhanh - Báo cáo khoa học: "Effect of ACTH and CRH on Plasma Levels of Cortisol and Prostaglandin F2α Metabolite in Cycling Gilts and Castrated Boars"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of ACTH and CRH on Plasma Levels of Cortisol and Prostaglandin F2α Metabolite in Cycling Gilts and Castrated Boars. | Acta vet. scand. 2005 46 249-256. Effect of ACTH and CRH on Plasma Levels of Cortisol and Prostaglandin F2a Metabolite in Cycling Gilts and Castrated Boars By A. Madej1 . Mwanza2 3 H. Kindahl2 and 5. Einarsson2 Department of Anatomy and Physiology 2Department of Clinical Sciences Centre for Reproductive Biology in Uppsala Swedish University of Agricultural Sciences SLU . Box 7011 SE- 750 07 Uppsala Sweden and 3Department of Clinical Studies School of Veterinary Medicine University of Zambia Box 32379 Lusaka Zambia. Madej A Mwanza AM Kindahl H Einarsson S Effect of ACTH and CRH on plasma levels of cortisol and prostaglandin F2a metabolite in cycling gilts and castrated boars. Acta vet. scand. 2005 46 249-256. - The present study was designed to evaluate the effects of synthetic ACTH 1-24 tetracosactid and porcine CRH on the plasma levels of cortisol and PGF2a metabolite in cycling gilts n 3 and castrated boars n 3 . The experiments were designed as crossover studies for each gender separately. Each animal received during three consecutive days 1 ACTH Synacthen Depot at a dose of 10 pg kg body weight in 5 ml physiological saline 2 porcine CRH at a dose pg kg body weight in 5 ml physiological saline or 3 physiological saline 5 ml . The test substances were administered via an indwelling jugular cannula in randomized order according to a Latin square. The administration of ACTH to cycling gilts resulted in concomitant elevations of cortisol and PGF2a metabolite with peak levels reached at and min respectively. Similarly the administration of ACTH to castrated boars resulted in concomitant elevation of cortisol and PGF 2a metabolite with peak levels reached at and min respectively. Cortisol peaked at 20 min after administration of CRH in both cycling gilts and castrated boars with maximum levels of nmol l and nmol l respectively. It can be concluded that administration of synthetic ACTH tetracosactid .

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