tailieunhanh - Báo cáo y học: " Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice. | Respiratory Research BioMed Central Research Open Access Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice Renate Paddenberg11 Philipp Stieger12 Anna-Laura von Lilien1 Petra Faulhammer1 Anna Goldenberg1 Harald H Tillmanns2 Wolfgang Kummer1 and Ruediger C Braun-Dullaeus 3 Address 1Institute of Anatomy and Cell Biology Giessen University Giessen Germany 2Department of Internal Medicine Cardiology Giessen University Giessen Germany and 3Department of Internal Medicine Cardiology Dresden University of Technology Dresden Germany Email Renate Paddenberg- Philipp Stieger- philippstieger@ Anna-Laura von Lilien - anlali@ Petra Faulhammer - Anna Goldenberg - Harald H Tillmanns - Wolfgang Kummer - Ruediger C Braun-Dullaeus - Corresponding author fEqual contributors Published 24 February 2007 Respiratory Research 2007 8 15 doi l465-992l-8-l5 Received 2 November 2006 Accepted 24 February 2007 This article is available from http content 8 l l5 2007 Paddenberg et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chronic hypoxia induces pulmonary arterial hypertension PAH . Smooth muscle cell SMC proliferation and hypertrophy are important contributors to the remodeling that occurs in chronic hypoxic pulmonary vasculature. We hypothesized that rapamycin RAPA a potent cell cycle inhibitor prevents pulmonary hypertension in chronic hypoxic mice. Methods Mice .