tailieunhanh - Báo cáo y học: " Endothelin-1 in exhaled breath condensate of allergic asthma patients with exercise-induced "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Endothelin-1 in exhaled breath condensate of allergic asthma patients with exercise-induced. | Respiratory Research BioMed Central Research Open Access Endothelin-I in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction Ziemowit Zietkowski Roman Skiepko Maria M Tomasiak and Anna Bodzenta-Lukaszyk Address Department of Allergology and Internal Medicine Medical University of Bialystok Poland Email ZiemowitZietkowski - Roman Skiepko - skiepek@ Maria MTomasiak - magdatns@ Anna Bodzenta-Lukaszyk - alergol@ Corresponding author Published 31 October 2007 Received 24 March 2007 Respiratory Research 2007 8 76 doi 1465-9921 -8-76 Accepted 31 October 2007 This article is available from http content 8 1 76 2007 Zietkowski et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Exercise-induced bronchoconstriction EIB is a highly prevalent condition whose pathophysiology is not well understood. Endothelins are proinflammatory profibrotic broncho-and vasoconstrictive peptides which play an important role in the development of airway inflammation and remodeling in asthma. The aim of the study was to evaluate the changes in endothelin-1 levels in exhaled breath condensate following intensive exercise in asthmatic patients. Methods The study was conducted in a group of 19 asthmatic patients 11 with EIB 8 without EIB and 7 healthy volunteers. Changes induced by intensive exercise in the concentrations of endothelin-1 ET-1 in exhaled breath condensate EBC during 24 hours after an exercise challenge test were determined. Moreover the possible correlations of these measurements with the results of other tests commonly associated with asthma and with the changes of airway inflammation after .