tailieunhanh - Báo cáo y học: "Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice. | Respiratory Research BioMed Central Research Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice Jigme M Sethi1 Augustine MK Choi1 William J Calhoun2 and Bill T Ameredes 2 Address division of Pulmonary Allergy and Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh PA 15213 USA and 2Division of Allergy Pulmonary Immunology Critical Care and Sleep APICS Division Department of Internal Medicine University of Texas Medical Branch Galveston TX 77755-1083 USA Email Jigme M Sethi - jmsethi@ Augustine MK Choi - choiam@ William J Calhoun - wjcalhou@ Bill T Ameredes - btamered@ Corresponding author Open Access Published 27 May 2008 Received 12 November 2007 Respiratory Research 2008 9 45 doi 1465-9921 -9-45 Accepted 27 May 2008 This article is available from http content 9 1 45 2008 Sethi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Nitric oxide NO and carbon monoxide CO in exhaled breath are considered obtainable biomarkers of physiologic mechanisms. Therefore obtaining their measures simply non-invasively and repeatedly is of interest and was the purpose of the current study. Methods Expired NO ENO and CO ECO were measured non-invasively using a gas microanalyzer on several strains of mice C57Bl6 IL-10- - A J MKK3- - JNK1- - NOS-2- - and NOS-3- - with and without allergic airway inflammation AI induced by ovalbumin systemic sensitization and aerosol challenge compared using independent-sample t-tests between groups and repeated measures analysis of variance ANOVA within groups