tailieunhanh - Báo cáo y học: "Simian virus 40 vectors for pulmonary gene therapy Luminita Eid1, Zohar Bromberg2, Mahmoud Abd "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Simian virus 40 vectors for pulmonary gene therapy Luminita Eid1, Zohar Bromberg2, Mahmoud Abd . | Respiratory Research BioMed Central Research Simian virus 40 vectors for pulmonary gene therapy Luminita Eid1 Zohar Bromberg2 Mahmoud Abd EL-Latif3 Evelyn Zeira2 Ariella Oppenheim3 and Yoram G Weiss 1 4 Address Department of Anesthesiology and Critical Care Medicine Hadassah - Hebrew University Medical Center Jerusalem 91120 Israel 2The Goldyne Savad Gene Therapy Institute Jerusalem 91120 Israel 3Department of Hematology Hadassah - Hebrew University Medical Center 91120 Jerusalem Israel and 4Department of Anesthesiology and Critical Care University of Pennsylvania School of Medicine Philadelphia PA 19104-4283 USA Email Luminita Eid - luminita25@ Zohar Bromberg - zoharb@ Mahmoud Abd EL-Latif - msa97@ Evelyn Zeira - evezeira@ Ariella Oppenheim - ariella@ Yoram G Weiss - weiss@ Corresponding author Open Access Published 29 October 2007 Received 28 March 2007 Respiratory Research 2007 8 74 doi 1465-9921 -8-74 Accepted 29 October 2007 This article is available from http content 8 1 74 2007 Eid et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Sepsis remains the leading cause of death in critically ill patients. One of the primary organs affected by sepsis is the lung presenting as the Acute Respiratory Distress Syndrome ARDS . Organ damage in sepsis involves an alteration in gene expression making gene transfer a potential therapeutic modality. This work examines the feasibility of applying simian virus 40 SV40 vectors for pulmonary gene therapy. Methods Sepsis-induced ARDS was established by cecal ligation double .