tailieunhanh - Báo cáo khoa học: "High Serum Folate Values in Lambs Experimentally Infected with Anaplasma phagocytophilum"

Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: High Serum Folate Values in Lambs Experimentally Infected with Anaplasma phagocytophilum. | Acta vet. scand. 2003 44 199-202. Brief Communication High Serum Folate Values in Lambs Experimentally Infected with Anaplasma phagocytophilum By K. E. Kleppa and 5. Stuen Department of Sheep and Goat Research Norwegian School of Veterinary Science Sandnes Norway. Folates are involved in nucleic acid protein and amino acid synthesis. In human serum it has been estimated that 60 to 70 of folates are bound to proteins Wagner 1985 . Folate binding proteins FBPs are therefore crucial to the assimilation distribution and retention of the vitamin folic acid and have been identified in various cells extracellular fluids and tissues from humans and several animal species. FBPs have different functions based on their biochemical properties and can be divided into 3 classes high-affinity folate binding proteins HFBP membrane-associated folate-binding proteins which function in the transport of folate compounds across cell membranes and cytoplasmic-binding proteins with a high affinity for specific reduced-folate compounds Henderson 1990 . Tick-borne fever TBF caused by the rickettsia Anaplasma phagocytophilum formerly Ehrlichia phagocytophila is a common disease in domestic ruminants on Ixodes ricinus infested pastures in Norway Stuen 1997 Stuen Bergstrom 2001 . During the acute infection A. phagocytophilum are found in cytoplasmatic inclusions in blood leucocytes mainly neutrophils. Up to 95 of the neutrophils can be infected. The rickettsemia is followed by a severe neutropenia lasting for 1-2 weeks Foggie 1951 Woldehiwet Scott 1993 . The reason for this neutropenia is not known but may be due to destruction and removing of infected cells Hudson 1950 Woldehiwet 1983 Rikihisa 1991 . Neutropenia in the peripheral blood of lambs is seldom observed except for lambs infected with A. phagocytophilum. Recently during a trace element deficiency study in Norway some lambs grazing on I. ricinus infested pastures had both a severe neutropenia cells l and increased serum .