tailieunhanh - Báo cáo y học: "Pulmonary cryptococcosis induces chitinase in the rat"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Pulmonary cryptococcosis induces chitinase in the rat. | Respiratory Research BioMed Central Open Access Pulmonary cryptococcosis induces chitinase in the rat Alfin G Vicencio1 Swati Narain2 Zhongfang Du1 Wang Yong Zeng2 James Ritch 1 Arturo Casadevall3 and David L Goldman 2 3 Address Department of Pediatrics Division of Respiratory and Sleep Medicine Albert Einstein College of Medicine and Children s Hospital at Montefiore Bronx USA 2Department of Pediatrics Division of Infectious Diseases Albert Einstein College of Medicine and Children s Hospital at Montefiore Bronx USA and 3Department of Microbiology and Immunology Albert Einstein College of Medicine Bronx USA Email Alfin G Vicencio - dvicenci@ Swati Narain - Zhongfang Du - zdu@ Wang Yong Zeng - wyzeng@ James Ritch - Arturo Casadevall - casadeva@ David L Goldman - dgoldma@ Corresponding authors Published 15 May 2008 Received 7 February 2008 Respiratory Research 2008 9 40 doi 1465-9921 -9-40 Accepted 15 May 2008 This article is available from http content 9 l 40 2008 Vicencio et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We previously demonstrated that chronic pulmonary infection with Cryptococcus neoformans results in enhanced allergic inflammation and airway hyperreactivity in a rat model. Because the cell wall of C. neoformans consists of chitin and since acidic mammalian chitinase AMCase has recently been implicated as a novel mediator of asthma we sought to determine whether such infection induces chitinase activity and expression of AMCase in the rat. Methods We utilized a previously-established model of chronic C. neoformans pulmonary infection in the rat